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What is a CDC Biosafety Level 4 laboratory?

Biosafety level 4 laboratories are used for diagnostic work and research on easily transmitted pathogens which can cause fatal disease. These include a number of viruses known to cause viral hemorrhagic fever such as Marburg virus, Ebola virus, Lassa virus, and Crimean-Congo hemorrhagic fever.

What do Level 4 labs do?

Known as biosafety level 4 (BSL4) labs, these are designed and built so that researchers can safely work with the most dangerous pathogens on the planet – ones that can cause serious disease and for which no treatment or vaccines exist.

What is a Level 4 biohazard?

Biohazard Level 4 usually includes dangerous viruses like Ebola, Marburg virus, Lassa fever, Bolivian hemorrhagic fever, and many other hemorrhagic viruses found in the tropics.

How many BSL-4 laboratories are there?

The BSL-4 laboratories are of two types; cabinet laboratory where all the work is performed in a Class III biosafety cabinet or similar physical containment with very carefully formulated precautions and suit laboratory where all the laboratory personnel are required to wear full-body, air-supplied suits protective …

What diseases are studied in a BSL-4 lab?

Ebola, smallpox, plague—the rogue’s gallery of highly infectious deadly pathogens is frighteningly long and their potential for havoc is great, which is why they can only be studied within the tightly controlled confines of a biosafety level 4 (BSL4) facility.

What type of diseases require biosafety level BSL-4 procedures and facilities when working with samples that may be infected?

Agents requiring BSL 4 facilities and practices are extremely dangerous and pose a high risk of life-threatening disease. Examples are the Ebola virus, the Lassa virus, and any agent with unknown risks of pathogenicity and transmission. These facilities provide the maximum protection and containment.

What biosafety level is Ebola?


Work with the world’s most deadly agents, including viruses that cause smallpox and viral hemorrhagic fevers, such as Ebola, is done at biosafety level 4 (BSL-4).

Why Is Ebola a Level 4 pathogen?

Diseases that have high fatality rates and have no known treatments are considered level 4 diseases. An example of a level 4 disease is Ebola virus, a disease that causes headache, muscle pain, fever, impaired liver and kidney function, and in some cases, death.

Is a virus a biohazard?

A biohazard is defined as any biological substances that pose a threat to the health of living organisms. By now you know that biohazards can include certain bacteria, viruses and medical waste.

What biosafety level is smallpox?

Biosafety Level 4

Biosafety Level 4 criteria are used when working with smallpox. Smallpox is very contagious and easily spread from person to person. Always use appropriate personal protective equipment including masks, laboratory coats, gloves, and eye or face shields when collecting and handling specimens.

What are 4 pathogens?

Pathogenic organisms are of five main types: viruses, bacteria, fungi, protozoa, and worms. Some common pathogens in each group are listed in the column on the right.

What are Level 4 hot agents?

These include a number of viruses known to cause viral hemorrhagic fever such as Marburg virus, Ebola virus, Lassa virus, and Crimean-Congo hemorrhagic fever. Other pathogens handled at BSL-4 include Hendra virus, Nipah virus, and some flaviviruses.

What is the difference between bsl2 and bsl3?

This is provided to demonstrate that BSL-2 is largely achieved through sound lab safety practices and BSL-3 is achieved through the addition of facility features and equipment designed for containment of aerosols to a foundation of sound lab safety practices.

How is the BSL-3 different from BSL-4?

BSL-4 builds upon the containment requirements of BSL-3 and is the highest level of biological safety. There are a small number of BSL-4 labs in the United States and around the world. The microbes in a BSL-4 lab are dangerous and exotic, posing a high risk of aerosol-transmitted infections.

What is the difference between bsl1 and bsl2?

The main difference in the work procedures followed in a BSL-1 laboratory and a BSL-2 laboratory is that employees in a BSL-2 laboratory will use a BSC as a primary barrier for potentially hazardous aerosols.

How much does it cost to build a BSL-4 lab?

The cost per gross square foot for a BSL-4 lab is in the range of $700 to $1,200.

How much does lab space cost?

According to a popular real estate website, office space in Orange County, CA costs on average $2.78 per square foot. In comparison, the national average cost of laboratory space was $24.60 per square foot in 2015.

How much would it cost to build a research lab?

A research building will most likely cost quite a bit more than a typical academic building. Construction costs can range from $350 to $500 per gross square foot for a research building, depending on program, as opposed to $150 to $250 for a typical academic building.